Police ranks in Georgetown have arrested a Sophia, Greater Georgetown resident after he was found in possession of an unlicensed weapon.The discovery was made sometime around 02:00h on Thursday at Leopold and Hadfield Streets, Georgetown.According to Police reports, ranks of the Anti-Crime Unit were on patrol duty when they observed the suspect in a Toyota Premio motorcar. The officers stopped the vehicle, in which the suspect was the lone occupant, and conducted a search during which a .380 Star Pistol was unearthed.The 34-year-old man has been taken into Police custody and is assisting with the investigation.
12 March 2003The Cabinet has decided to retain the current 400-member National Assembly as well as the present proportional representation electoral system for the 2004 elections.The decision, taken last week, follows the recommendations made by the task team instituted by President Thabo Mbeki in 2002 to formulate parameters for a new electoral system in the country.Releasing its final report in Cape Town this week, the team, headed by Frederick van Zyl Slabbert, recommended that South Africa be divided into 69 constituencies, each with three to seven MPs, for future parliamentary polls.However, it said it realised there was no way this could be implemented in time for the 2004 general elections.According to the task team’s recommendations, the boundaries of the 69 constituencies would be drawn along existing provincial, municipal and metropolitan boundaries.Political parties would then draw up lists of constituency candidates similar to the provincial and national lists used in the current system. The constituency representatives would account for 300 members of the National Assembly, the remaining 100 being drawn from a closed national list.The new system, which is likely to be used for the first time in the 2009 polls, will replace the proportional representation system used in the 1994 and 1999 general elections.Briefing the media following the release of the report, Van Zyl Slabbert said consensus was reached that changes to the current electoral system should be evaluated in terms of the values of fairness, inclusiveness, simplicity and accountability.Referring to the question of floor-crossing legislation that is currently being debated in Parliament, Van Zyl Slabbert said the majority view was that the current system was opportunistic and inappropriate and did an injustice to the principle of proportionality.“If the accessibility and distance between the voter and representative is taken as the guiding principle, then floor-crossing can be considered. There is nothing inherently undemocratic about it, it depends very much on the kind of electoral system”, Van Zyl Slabbert said.Also addressing journalists, Home Affairs Minister Mangosuthu Buthelezi said the electoral task team report brings a new and better electoral system that will further promote democracy in the country.“From the outset, my view was that by establishing a task team, the debate and drafting on new legislation would be moved away from political tensions and truly reflect the needs of our democracy and the views of civil society”, the minister said.According to last week’s Cabinet statement, the new government elected in 2004 will review the report in preparation for the 2009 elections.Source: BuaNews
Desde as longas extensoes de areia de praias inexploradas da Costa Ocidental ate as orlas maritimas subtropicais de Maputaland, ha uma praia para todos os gostos. Veja o nascer do sol sobre o oceano Atlantico ou Índico, ponha o bronze em dia ou seja mais activo – a África do Sul oferece dos melhores surf, windsurf e mergulho do mundo. E depois ha as baleias…O PARAÍSO DOS DESPORTOS NÁUTICOSOs nossos programas de mergulho tem florestas de algas gigantes nos recifes de coral, o surf inclui programas divertidos na praia, tubos ocos e alguns monstros a serio, alem de termos um optimo surf ski ou as ondas de esqui, caiaque e vela.Surf, windsurf, kitesurf, caiaque oceanico“A África do Sul e dos melhores paises do mundo para a pratica de surf, com um cenario costeiro espantoso, boa qualidade de surf em qualquer epoca do ano, um nivel de vida barato e ao mesmo tempo de grande nivel, alem de uma cultura unica de que se pode orgulhar,’ diz Steve Pike, editor da Wavescape.Poucos seriam os visitantes a discordar. Ha centenas de surf breaks por todo o pais – cerca de 50 a uma hora de carro da Cidade do Cabo.Desde a ondulaçao segura para crianças e principiantes ate aos breaks epicos que assustam mesmo os concorrentes mais audazes nas competiçoes internacionais que se realizam em Junho e Julho.A area do Cabo Oriental em volta do Cabo de Sao Francisco, Jeffreys Bay e Port Elizabeth – conhecidos em conjunto como Jay Bay pelos surfistas locais – conhecido em todo o globo pela qualidade das suas ondas.Muitos dos albergues para os chamados turistas de mochila espalhados um pouco por todo o pais estao preparados para aluguer de pranchas, surfaris guiados e liçoes de surf e em Durban e na Cidade do Cabo existem boas escolas de surf.A África do Sul tem locais assombrosos para a pratica de windsurf e kitesurf. Langebaan, perto da Cidade do Cabo, e internacionalmente reconhecida como um dos pontos de encontro mais badalados para todo o genero de pratica de surf – mas ha mais.Uma maneira mais acessivel de experimentar o prazer do mar e andar de caiaque. Existem viagens guiadas em volta da Cidade do Cabo, Hermanus, Knysna, Plett e Durban.VelaA costa maritima da África do Sul e uma das mais desafiantes do mundo da vela, com poucos portos, muitas tormentas e, mares frequentemente bastante alertados. Nao e por isso uma boa opçao para levar um barco alugado.No entanto, e um lugar optimo para aprender vela – ha escolas da modalidade na Cidade do Cabo, Porth Elizabeth e Durban – e disputam-se aqui algumas das regatas mais famosas do globo. As regatas locais sao inumeras tambem e a regata da Cidade do Cabo ate ao Rio de Janeiro e uma das mais celebres, atraindo um enorme contingente de barcos.MergulhoSe precisa que o convençam acerca da gravidade e do perigo da costa sul africana, nao precisa de ir longe – basta ver os naufragios mais recentes ou os que ficaram na historia – todos eles grandes tragedias, mas ainda assim boas noticias para os mergulhadores. Porem, nao se preocupe, temos mais para lhe oferecer do que esses sitios desoladores. O nosso ambiente submarino e do mais diverso e do mais belo que existe, com infinitos sitios fantasticos para mergulhar.Possuimos uma linha costeira incrivelmente longa, dos 35º S aos 27º S, que nao fica propriamente ao alcance normal do mergulho tropical. Apesar disso, as correntes que descem de Moçambique pela costa oriental trazem aguas quentes e tropicais e Sodwana Bay, no KwaZulu-Natal, tem os recifes de coral mais a sul do mundo.Encontrara aqui todo um conjunto de peixes com cores magnificas e algumas grandes lesmas do mar, incluindo a extravagante “dançarina espanhola’. Tubaroes baleia, tartarugas, golfinhos e tubaroes de areia sao muitas vezes vistos em zonas especificas.À medida que vamos descendo a costa, o ambiente submarino muda gradualmente ate que, quando chegamos a Cidade do Cabo, ja estamos a mergulhar em aguas frias mas encontraremos lindissimas florestas de algas gigantes – onde podemos flutuar por debaixo da agua e admirar o surpreendente mundo colorido dos recifes.Ha escolas de mergulho em praticamente todos os sitios, um grande numero delas, para nossa admiraçao, na cidade de Joanesburgo, tao isolada do mar, onde as pessoas fazem o seu treino antes de partirem para a Sodwana Bay para praticar mergulho.Mas tome sempre muito cuidado com as zonas interditas. Um voo do nivel do mar para Joanesburgo pode demorar so uma hora, mas sobe-se quase 2.000 metros (7.000 pes) de altitude – e isso sem considerar o voo. O que representa um enorme risco, por isso deve ajustar o seu itinerario de modo a incluir um dia de visitas e excursoes, compras ou idas a praia antes de ir fazer mergulho e viajar em Joanesburgo.CAPITAL MUNDIAL DA BALEIAA África do Sul e um dos melhores destinos mundiais para observaçoes dos mamiferos marinhos. No inicio de Junho, as baleias franco astrais deixam o seu habitat no Antarctico para ziguezaguear nas aguas (relativamente) quentes da costa do Cabo.Experiencias com a vida selvagemÉ claro que os grandes mamiferos da África do Sul nem sempre estao na linha da costa.Aqui acasalam, tem as crias e geralmente permanecem, ocasionalmente jogando a cauda para o ar ou pondo as cabeças de fora para ver por onde param as pessoas.Na Cidade do Cabo pode ve-los da estrada, em qualquer sitio ao longo da False Bay (Baia Falsa) e, se estiver num sitio suficientemente alto, pode ve-los perfeitamente no litoral ocidental.A cidade de Hermanus auto-proclamou-se a capital mundial da baleia – e nao anda longe da verdade. Estes animais imensos aproximam-se as vezes a escassos metros da costa e sao claramente visiveis do passeio panoramico no cimo do penhasco.Mais a leste, a cidade de Plettenberg Bay tambem se auto-proclama capital da baleia – e igualmente com fortes motivos para o fazer. As baleias franco austrais podem ser vistas na baia entre Junho e Novembro e as baleias jubartes ou corcundas migratorias vem aqui por pouco tempo, mais ou menos em Maio ou Junho e depois, na sua viagem de regresso, entre Novembro e Janeiro.As baleias de Bryde ou orcas sao vistas ocasionalmente, ao passo que os golfinhos nariz de garrafa e os golfinhos corcundas sao residentes todo o ano. Uma colonia de procriaçao de focas do Cabo completa a impressionante colecçao de mamiferos de Plettenberg Bay.É em Plett que a industria de observaçao de golfinhos e baleias esta mais bem organizada, com viagens de barco, caiaque e aeronaves. A observaçao, as distancias e o tempo gasto com cada animal sao estritamente controlados para que nao haja a minima interferencia.Na costa mais a norte de KwaZulu-Natal, os golfinhos de nariz de garrafa e os golfinhos corcundas tambem sao frequentemente observados dos barcos.Reporter infoSA, incorporando material de Turismo Sul Africano
22 March 2016Eddie Izzard finished his 27th marathon in 27 days today. Raising £1,350,000 for #SportRelief. An inspiration! pic.twitter.com/P83CckMSYc— BreatheSport (@BreatheSport) March 20, 2016 *UPDATE: On 20 March 2016, British comedian Eddie Izzard completed his 27 marathons in 27 days challenge, reaching the finish line in Pretoria. Izzard, inspired by the life and work of Nelson Mandela to complete his personal challenge and raise money for the Sport Relief charity, appropriately ended his 1 139 km journey at the feet of the Madiba statue in the gardens of the iconic Union Buildings. Physically, mentally, could you do an Eddie Izzard?Can you push your endurance limits?https://t.co/VS5JFGwZRE pic.twitter.com/ytaeR0TJzK— BBC Sport (@BBCSport) March 21, 2016“It’s been the hardest thing I’ve ever done, and I’m very tired,’ Izzard told the BBC in front of Mandela’s statue. The network broadcast his finish live. “Thank you to everyone who has donated. This was tough, so don’t do this at home.”Eddie Izzard, the cross-dressing British comedian, is in the midst of running 27 marathons in 27 days across South Africa. The epic adventure is a tribute to Nelson Mandela and is to raise funds for charity. He plans to end his journey in Pretoria on 20 March.pic.twitter.com/gUkiZ2mMPT— Eddie Izzard (@eddieizzard) March 11, 2016Izzard has so far raised over R 5 million for the Sport Relief charity, a traditional British initiative that brings sports stars and celebrities together for broadcasts and challenges that raise money for a number of global causes, including HIV/Aids research, poverty eradication and education.pic.twitter.com/TBZee3VWma— Eddie Izzard (@eddieizzard) March 15, 2016He began his epic quest on 24 February in Eastern Cape – the area where Mandela was born – and, as of 15 March, is rounding Western Cape, completing marathon 21. His end point will be at the Union Buildings in Pretoria at the end of March. Izzard’s progress is being tracked live on his various social media accounts, as well as on a live webcast on the BBC 3 website.Just started running in South Africa. Trying to run 27 marathons in 27 days for @sportrelief pic.twitter.com/m6RoybA72t— Eddie Izzard (@eddieizzard) February 23, 2016<br/>He has been preparing for the ambitious journey for the last five years. Izzard covered the length of the United Kingdom in 2009, running 43 marathons in 51 days, a total of almost 2 000 kilometres, in seven weeks. He attempted the South African route in 2012, but withdrew with health problems, promising that he would return to the challenge as soon as he was better equipped. In addition to professional training, Izzard is being well supported by a team of British and South African endurance experts.South African Comrades legend Bruce Fordyce joined Izzard along the route to offer advice on how to handle the local running conditions.Running with Comrades running legend @BruceFordycerun and my physio Tim. A great afternoon https://t.co/06erhBxw65 pic.twitter.com/tQUijNkirh— Eddie Izzard (@eddieizzard) March 12, 2016The money raised from the challenge will be used to help transform the lives of some of the most disadvantaged people in the world’s poorest communities.Izzard told the BBC of his inspiration for the grand undertaking: “I was inspired to run the marathons after seeing the film Invictus, named after the poem by English writer William Henley, which was one of Nelson Mandela’s favourite poems while in prison. It is a beautiful poem about being the master of your own fate and destiny.Mandela used it to give himself determination to keep himself going and keep his spirit alive. (Hearing the words) I knew I had to run in South Africa, as (not only) a salute to the great man, (but) also a salute to all who struggled and fought against (oppression and inequality).”The entire trip is also being filmed as a documentary covering the life of Mandela, as well as the everyday lives of ordinary South Africans Izzard meets along his way.In South Africa – meeting the locals in the Eastern Cape while attempting 27 marathons in 27 days for @sportrelief pic.twitter.com/XBXE8zG7gZ— Eddie Izzard (@eddieizzard) February 25, 2016Source: News24
Related Posts steven walling IT + Project Management: A Love Affair 3 Areas of Your Business that Need Tech Now Lithium has changed its game. Once limited to customer communities, the company has moved to become a complete social CRM for the enterprise. Lithium’s new approach creates a flow of information from the social web into your community. The result is the creation of valuable content, community-driven support, and the identification of engaged customers. The only stumbling block may be the ambiguity behind the company’s new messaging. Defining Social CRMReleased this week, Lithium’s new suite takes their previously forum-centric software and ushers it in to a Web dominated by Facebook and Twitter. Unfortunately, they’ve decided to brand themselves with a buzzword that lacks a fixed meaning in the market currently. The social CRM (or CRM 2.0) label may be accurate when applied to Lithium, but it depends on which definition you pick. We’ve seen vendors tout CRMs with internally-focused collaborative features called as such, but what it commonly means is CRMs connected in some way to public social media or support systems. With such a wide ranging use of the term, Lithium is likely to have a hard time maintaining a clear and focused message on what the software actually does. Social Media MiddlemanAll marketing aside, there is substance to what is new about the software. Lithium acts as content repository and community site like before, and this is retained in what’s now quaintly called the “tribal knowledge base,” formed of something like a wiki, instead of just forums. Lithium is also is now acting like a channel between the consumer Web, your community, and your company CRM. They integrate with leading CRMs like Salesforce.com, and they draw in blog posts and Twitter search. For the Twitter tie in, the widget can be embedded in just about any page, and the keywords can be set on a page-by-page basis. If there’s a particularly relevant discussion going on, then a tweet can be used to seed a forum thread.Stiff CompetitionLithium is one of the top community solutions for the enterprise, but in this new space, they’re facing some determined competition. Many see the core of social CRM as being a way to monitor public conversations about the enterprise from within your usual CRM software. In that frame of mind, Lithium is going to have a hard looking more useful than tools such as Oracle social CRM and Salesforce.com’s Service Cloud, which already integrates with Twitter.Compared to other examples of social CRM, the core base for Lithium is still going to be those who want a customer community that identifies and rewards engaged people. Whether or not the customers that make these communities tick are going to get excited by integration with the social media spectrum is the question that remains to be answered. Tags:#enterprise Massive Non-Desk Workforce is an Opportunity fo… Cognitive Automation is the Immediate Future of…
The dream sequence stared me in the face. And it seemed straight out my favourite Hollywood film The Last Samurai–cherry blossoms floating in the crisp mountain air as Katsumoto, the rebel Samurai warrior, lay dying in the arms of friend and trusted general Nathan Algren. The poignancy of the scene brings a lump to my throat each time I watch the film. Only this time the feelings were drastically different, much like some of the details of the bigger picture.The cherry blossoms had given way to magnolias, equally pretty in pink, beige and dazzling white. And my location was not Japan, the land of the Samurais. I was at Alishan, a hillstation on the island nation of Taiwan. It was too early to call it spring but the magnolias were there in full bloom as was the nippy cold.Neatly laid out before my eyes was a forest of cedar and cypress, and a walking trail–it also included wooden and rope bridges-beckoned me to join the scores of holidaymakers scattered across the Divine Tree Zone.I chose to punctuate the activity with some mental arithmetic. I stopped at places to admire tree trunks in curious shapes–face of a hog, bull’s head and so on–while, at times, I spent minutes in making fresh notes of all that I had seen of Taiwan since arrival. Coming from a family that greatly admires Netaji Subhas Chandra Bose, I had always associated the country with his untimely ‘death’. Books on history still proclaim that it was a plane crash in Taipei that ended his life. And it was as recent as 2005 that an inquiry commission challenged the theory. It was this debate that whetted my interest in Taiwan. But it’s another story that almost no one–the general public in Taiwan–has heard of Bose. Or even Mahatma Gandhi for that matter. However, India and its food is something that is much talked about. So don’t be surprised if someone comes up and shouts “samosas” at you. Or if Mohit Chauhan’s voice emanates from a music system playing at a Taipei tea room.Resilient and friendly, the Taiwanese are also one of most advanced in terms of technological development and civic infrastructure. The proof lies in the concrete road that winds its way up to Alishan. At first glance there is nothing that is out of the ordinary. Except the tea gardens that skirt the road, perhaps. But consider that it was rebuilt in less than 12 months since floods obliterated its existence last year and you know what I am talking about.Work is still under progress and very soon, the Alishan Forest Rail–a narrow gauge train, which lost its track to the floods–will be up and running. Just the thought of chugging through a forest of magnolias brought me back to the present, with, of course, a smile. I trudged along the forest trail and soon found myself at the Sister Ponds. My excitable guide plied me with tales of unrequited love and sacrifice related to the waterbodies. I smiled again, this time reflecting upon the intangible connection between hillstations and stories of love, suicide and betrayal.I left quiet and solitude behind at Alishan as I started for Chiayi City, the second largest in Taiwan after the capital. Ask tourists and chances are that nine out of ten don’t know that Chiayi exists. The city after all has little to offer to the discerning traveller. A sprinkling of swanky malls with all the high-end brands you could think of and a pottery museum is hardly meat enough for a tourist. However, I was in Chiayi for a different reason altogether. It was the first week of the new Chinese year and the city was kitted out for the Lantern Festival.Much before search engines invaded our knowledge domain, my father introduced me to colourful Chinese New Year celebrations through images in newspapers. My native city Kolkata boasts a sizeable Chinese population so I was not alien to paper dragons, gaudy masks and radiant lanterns. Strangely, however, I fell back upon the addictive search engine to do my homework on the festival before the trip. The results it threw up were enough to convince me that I was headed for a grand spectacle.And yes there were lanterns, thousands of them. Lanterns hanging at every street corner from window boxes, lamp posts, electric poles, trees, telephone wires and even billboards. The highest concentration, however, was at the main festival grounds. It was packed to the gills with not just Chiayi residents but also visitors from mainland China and other corners of the little island. I revelled in the strange beauty and also the cacophony of community celebrations as I went about the dazzling grounds. I noted that there were no security checks, no random frisking or even the sight of a metal detector. All’s not wrong with the world, I told myself gladly, before I devoted my attention to the amazing display of light.A semi-crouching tiger, the majestic beast that represents the current year, towered above everything else. Children crowded around an illuminated zoo of sorts while couples, young and old, kissed under lanterns. Some youngsters sported glowing horns. I moved closer to an army of shining warriors who reminded of my favourite samurais. Horses, palaces, gardens, monasteries and even odd geometric shapes… there were all these and much more. It seemed we were living the first day of Creation. The day a divine entity demanded, “Let there be light”.My venture towards the crowded food court was cut short by an announcement that the Vice President of Taiwan, also the chief guest at the Lantern Festival, had arrived. Clashing of cymbals, beating of drums and yodelling singers signalled the beginning of the celebrations. A series of spectacular choreography–both martial and traditional–held me and at least another 200 in the press box, in thrall for the next hour. We struggled for the best shots of the centrestage flooded with dancers in blazing red, yellow and black costumes. All around the grounds, mobile phone cameras cast a strange glow on the evening and flashbulbs blinked out darkness.The next big thing was the fireworks display, which, too, began with the clashing of cymbals. Columns of smoke arose from the base of the tiger, sending out glittering streaks across the cloudless night sky. Golden, silver, green and maroon sparkles flitted across the city’s skyline, making it a night to remember. I had heard much of fireworks at Times Square. This one, I concluded, was no less for me. When in Taiwan, you don’t miss Taipei. It was a given that my trip should end at the capital. I had only two nights in Taipei out of which I chose to spend one in Shilin, a night market that is all about food. This, of course, came only after I had paid tribute to the architect of the nation–Chiang Kai Shek–at his memorial and watched the rather meticulous changing-of-guard ceremony at Martyrs Shrine. The flavours at Shilin were too strong to induce hunger in me. But the latent shutterbug came to the fore as I captured Taipei at dinner. Rows of shops stand cheek by jowl in this crowded market. And frenetic is a sorry understatement of the pace of activity that puts Shilin in the league of Asia’s most colourful food markets. I stopped every 20 metres, trying to muster courage to bite into the fluffy oyster omelettes or the oversized pork sausages on the grill. I jostled with swelling crowds and temptations with equal gusto and decided to starve the foodie in me. And that’s a choice I don’t regret. For keepsake I have moments of the market that can take me through the blandest meal and the longest day. Fact fileGetting there: Fly Delhi-Taipei-Delhi on China Airlines. Fare: Rs. 32,000 approx. Taiwan has an excellent road network. Most places can be reached within a few hours by road from Taipei.When to go: Except peak summer, Taiwan is an all-year destination. Plus saysStayAlishan House, www.alishanhouse.com.twNice Prince Hotel, Chiayi City, www.niceprince.com.twMiramar Garden, Taipei, www.miramargarden.com.twEat: Steamed soup dumplings at Din Tai Fung, a restaurant in Taipei.Shop: Oolong tea from one of Taipei’s many tea houses.See: The Jadeite Cabbage at Taipei’s National Palace Museum.Biking at Sun Moon lakeA quick getaway from Taipei is the Sun Moon Lake, which encloses its own island. A popular activity at Sun Moon Lake is biking, which draws visitors from mainland China and other parts of Taiwan. The 33-km biking trail around the lake takes approximately two-and-a-half hours to complete. You can hire bicycles from the Sun Moon Lake Youth Activity Centre (details on www.sunmoonlake.gov.tw). Visitors in spring and summer can expect the additional treat of cherry blossoms along the biking trail.advertisementadvertisementadvertisement
17Oct State Rep. Hank Vaupel Weekly Column: Oct. 7, 2018 Categories: News,Vaupel News I want to thank Sam Champagne, House policy committee advisor of the House Health Policy Committee, for his service in assisting with legislation. Sam Champagne was presented a tribute for his work and dedication to the Michigan House. He is leaving for a position in the private sector, and we wish him well on his new endeavor.***I recently participated in the Brighton Area Chamber of Commerce Power Lunch where I served on a panel to discuss legislation and public policy issues trending locally, statewide and nationally. Congressmen Mike Bishop, state Senator Joe Hune and state Rep. Lana Theis also attended the event. National and state issues were discussed with active audience questions. It was a great opportunity to meet with local residents and discuss community updates.***This week, I was invited by Lake Trust Credit Union to help with gardening maintenance for LACASA. LACASA helps hundreds of people by protecting and empowering victims and survivors of child abuse, domestic violence and sexual assault. I want to thank the Lake Trust employees for their work to help assist LACASA for several hours by completing the needed garden weeding and mulching. Having dedicated volunteers help local businesses keeps the community together.***On Tuesday, I attended the Howell Chamber of Commerce Good Morning Livingston breakfast where presentations were made by several Fowlerville businesses. The speakers shared projects they are working on, and what residents can look forward to with recent expansion plans and responsibilities their businesses face.***Please join me for my October office hours on Friday, October 19 at the following times and locations:· 2:30 to 3:30 p.m. at Fowlerville Farms, 941 S. Grand Ave. in Fowlerville;· 4 to 5 p.m. at Biggby Coffee, 11325 W. Highland Road in Hartland; and· 5:30 to 6:30 p.m. at All Star Coney Island, 934 Michigan Ave. in Howell.I look forward to seeing you and hearing your thoughts!***If you have any ideas, comments or questions for my office, please do not hesitate to call us at 517-373-8835 or send an email to HankVaupel@house.mi.gov. We are happy to hear from you!***PHOTO INFORMATION: (left to right) State Rep. Edward J. Canfield, D.O., state Rep. Hank Vaupel, Sam Champagne, and Speaker of the House Tom Leonard presented a tribute to Sam Champagne for his work at the Michigan House of Representatives.
Reviewed by Alina Shrourou, B.Sc. (Editor)Oct 10 2018In the human brain, nerve cells – so-called neurons – care for the transmission of electrical signals. They form the functional component responsible for sensations, stimuli and memories. In the presence of dementia, there is an adsorption of proteins outside the neurons, which then leads to the death of the neuronal cells. How to prevent the death of neurons is still the subject of scientific research today.In a recent transnational research project funded by the EU Joint Program on Neurodegenerative Disease Research (JPND), which is funded in Germany by the German Federal Ministry of Education and Research (BMBF), researchers are now trying to address this question.While project partners in Italy, Great Britain, Belgium and the USA investigate the exact processes in the brain, the MPI-P explores methods to transport drugs. The overcoming of a natural barrier in the body – the so-called blood-brain barrier – represents the main challenge. Drugs to be used in the brain must be able to pass this barrier first before acting in the brain.For this purpose, the Mainz scientists are working on nanocapsules that are supposed to overcome the barrier. On the one hand, it has to be taken care on a long circulation time of the nanocapsules in the blood in order to increase the probability of interaction with the target cells in the affected brain areas. For this, it is important to design the nanocapsules so that they are not directly excreted by kidney or liver. On the other hand, special “address labels” – consisting of proteins – must be placed on the capsule surface in order to be recognized and absorbed by the target cells, much like a key with a lock. “We are still filling our nanoscale capsules with dye,” says Dr. Svenja Morsbach, group leader in the department of Prof. Katharina Landfester at the MPI-P. “If the transport through the blood-brain barrier with the nanocarriers works, we hope we can simply exchange the dye for a suitable drug.”Related StoriesWorld’s first 3D heart printed using patient’s own cells and biological materialsComing soon: New home blood-testing device for people with chronic illnessesNanotechnology treatment reverses multiple sclerosis symptoms in miceThe partners involved in the project in Italy, the United Kingdom, Belgium and the USA are examining the exact processes in the brain in parallel with the development of the transport system in Mainz. Here, so-called “exosomes” and “neurotrophic factors” are of major interest. Exosomes are small “miniature cells” that can be released by real cells to communicate with each other. These have a dimension of only about 100 nanometers – that is 100 billionths of a meter in size. At the same time, “neurotrophic factors” are biochemical messengers responsible for the growth and survival of nerve cells. The interaction of exosomes and neuron-stimulating factors is seen as the main focus for the understanding of dementia by researchers.The project is designed for a period of three years and is funded with over one million euro, of which a share of more than 400,000 euros is attributed to the subproject of the Mainz scientists. The researchers hope that understanding the disease itself and developing a functioning transport system will be an important step in the treatment of dementia. Source:http://www.mpip-mainz.mpg.de/5458095/PM2018-23
gaming and lottery August 21, 2018 To rebuild lives, Kerala needs doctors, nurses, packed food: Alphons 2 Chief Minister Pinarayi Vijayan COMMENTS flood RELATED Kerala GST SHARE SHARE EMAIL Published on COMMENT As Kerala struggles to raise resources for rehabilitation in the wake of devastating floods, the state government today demanded that it should be allowed to impose a 10 per cent cess on the GST and also introduce a special lottery.This decision was taken at a state Cabinet meeting chaired by Chief Minister Pinarayi Vijayan here today.The flood-ravaged state has asked for the GST council’s permission to introduce 10 per cent cess on the GST as part of its efforts to mobilise more resources for rehabilitation, besides planning to introduce a special lottery, a government press release said.The Cabinet also decided to accept the materials supplied by individuals and voluntary organisations outside the state and distribute the same in relief camps.In view of the flood situation, all plantation workers will be given 50 kg of free ration.Fire department personnel, police and revenue officials as also fishermen who took part in the rescue operations will be given a certificate of the Kerala State Disaster Management Authority in recognition of their services, it said.The devastating deluge has left 223 dead and over 10 lakh people homeless over the last fortnight. 373 dead in Kerala since May 30 due to rains, floods, landslides SHARE