Rabat – Moroccan authorities criticized, Friday, the Human Rights Watch (HRW)’s “deliberate underestimation, in its latest report, of Morocco’s human rights achievements and related reform process.In a statement released by the Inter-Ministerial Delegation for Human Rights (DIDH), Moroccan authorities noted, after reading the NGO document presented at a conference in Rabat, the existence of a “paradox” between the body’s statement which says that HRW is satisfied with how its actions are taking place in Morocco in a climate of freedom, and its “underestimation” of Morocco’s human rights efforts.Moroccan authorities criticized the content of a HRW statement on human rights in Morocco with a title that “deliberately underestimates” the country’s accomplishments, voicing the Kingdom’s refusal of any evaluation or criticism based on allegations. According to Rabat, though Morocco is open to any observations and criticism on human rights or any other field, it refuses any evaluation or criticism based on allegations by a unique source, mainly cases/parties quoted by the HRW report, it added.Rabat has already expressed its opinion about the content of its report on human rights in the camps of Tindouf, particularly, but some conclusions and recommendations were not taken into account.Among these recommendations is the call on the said body to schedule a high-level meeting in New York to shed light on interaction methods with the NGO and ensure more transparency in all cooperation initiatives, but there was no response to this call.The Moroccan government affirmed that the major reform process taking place in Morocco is a process that is “durable, gradual, participatory and open to all concerned stakeholders including national and international NGOs.”“This process did not witness any deterioration, and its dynamic was stepped up after enforcing the 2011 constitution,” it concluded.MWN with MAP
Jean Ziegler, the Special Rapporteur on the right to food, says 842 million people were permanently or gravely undernourished last year, an increase of 2 million on the previous figures. Hunger levels have now risen every year since the World Food Summit in 1996 called for global action to stem the trend.In a report to the General Assembly, Mr. Ziegler says it is indefensible that so many small children are still dying because they do not have enough food to eat.”How can we continue to live with this shame?” he asks, declaring that the time has come “to enforce the right to food.”Mr. Ziegler says hunger is neither inevitable nor acceptable. “We live in a world that is richer than ever before and that is entirely capable of eradicating hunger,” he writes. “There is no secret as to how to eradicate hunger. There is no need for new technologies. There is simply the need for political commitment to challenge existing policies that make the rich richer and the poor poorer.”The expert expresses doubt that the world can meet the Millennium Development Goal (MDG) that calls for the halving of the number of hungry people by 2015. While some countries have made gains in the last decade, many others have regressed, including India, Indonesia, Nigeria, Pakistan and Sudan.The Rapporteur states he is particularly concerned by the situation in Sudan, the Democratic People’s Republic of Korea (DPRK), the occupied Palestinian territories and Cuba.Mr. Ziegler calls for urgent action by Khartoum and Pyongyang to protect the citizens of their countries, and says the Israeli Government must respect its obligations as the occupying Power so that Palestinians enjoy the right to food. He also urges the United States “to refrain from unilateral measures that affect the right to food” of Cubans.
by Malcolm Morrison, The Canadian Press Posted Feb 22, 2013 8:27 am MDT Stocks recover equilibrium after string of losses on Fed stimulus concerns TORONTO – The Toronto stock market closed higher Friday after worries about the future of U.S. economic stimulus drove the TSX lower over the previous two sessions.The S&P/TSX composite index advanced 61.65 points to 12,701.63 with all sectors positive, except for tech stocks, while the TSX Venture Exchange advanced 10.71 points to 1,144.68.The Canadian dollar was down 0.2 of a cent at 97.96 cents US. It had earlier hit an eight-month low of 97.51 cents US amid data showing lower than expected retail sales and tame inflation figures.Retail sales fell 2.1 per cent in December, led by a decrease in vehicle sales. That was much more than the 0.3 per cent decline that economists had expected. The drop followed five consecutive monthly gains in retail sales.Excluding sales at motor vehicle and parts dealers, retail sales decreased by 0.9 per cent.Meanwhile, Canada’s already low inflation subsided further in January. Statistics Canada says the consumer price index rose 0.5 per cent in January compared with a year earlier, a smaller increase than the 0.8 per cent gain in December and the smallest increase since October 2009.A strong earnings report from tech giant Hewlett Packard helped push New York indexes well into positive territory after two days of declines, sparked by the release of minutes from the Fed’s latest policy meeting. They showed that some policy-makers were worried that the bank’s US$85 billion in monthly bond purchases could eventually unsettle financial markets or cause the central bank to take losses.The Fed’s bond purchases, commonly known as quantitative easing, are designed to boost the U.S. economy by increasing liquidity in financial markets.“It’s definitely been a positive in reflating asset prices including the stock market,” said Patrick Blais, managing director and portfolio manager at Manulife Asset Management.“But the Fed is cognizant that it needs a sustainable economic backdrop to retrench completely so we expect that the risk (of winding up QE) has arisen but it’s not a given, it’s not confirmed and will depend on the progression of economic fundamentals.”The Dow Jones industrials gained 119.95 points to 14,000.57, the Nasdaq was ahead 30.33 points to 3,161.82 and the S&P 500 index advanced 13.18 points to 1,515.6.Personal computer maker Hewlett-Packard Co. on Thursday reported earnings of $1.2 billion, or 63 cents per share, down 16 per cent from a year ago. Ex-items, HP would have earned 82 cents per share, well above the average estimate of 71 cents per share among analysts surveyed by FactSet. Revenue fell six per cent to $28.4 billion, about $470 million above analysts’ projections.In a show of confidence, HP had provided an earnings forecast for the February-April quarter that was higher than analysts’ projections and its stock ran ahead 12.28 per cent to US$19.20.Investor sentiment also got some lift from data showing that a key survey of German business optimism rose sharply in February. The Ifo index rose to 107.4 from 104.3 in January. It was the fourth monthly increase in a row, well above the 104.9 points expected by financial market analysts and supported the feeling that Europe’s biggest economy can avoid slipping into recession.Friday’s figure followed an in increase in the ZEW index based on surveys of investment analysts released Tuesday.Commodity prices were mixed following a string of steep losses.Commodities have been punished by a U.S. dollar which strengthened after the release of the Fed minutes on Wednesday. Also, oil prices had been undercut by data showing U.S. oil inventories rose last week by a much more than expected 4.14 million barrels.The April crude contract on the New York Mercantile Exchange ticked 29 cents higher to US$92.71 a barrel after tumbling about US$4 over the previous two sessions. The energy sector gained 1.2 per cent and Cenovus Energy (TSX:CVE) improved by 41 cents to C$32.78 and Canadian Natural Resources (TSX:CNQ) gained 38 cents to $30.37.The base metals sector was up 1.16 per cent while March copper was down two cents at US$3.53 a pound after losing almost 10 cents over the previous two sessions. Lundin Mining (TSX:LUN) climbed 26 cents to C$4.86 while Sherritt International (TSX:S) gained 17 cents to $5.59.Lift was also provided by the financial sector, up 0.49 per cent as traders look ahead to earnings from most of the big Canadian banks next week. Bank of Montreal (TSX:BMO) climbed 40 cents to $63.11 while Scotiabank (TSX:BNS) was up 42 cents to $60.34.Telecoms also advanced with Rogers Communications (TSX:RCI.B) ahead 68 cents to $48.85.The gold sector was up about 0.2 per cent late in the morning as the April bullion contract declined for a third day, down $5.80 to US$1,572.80 an ounce. Iamgold Corp. (TSX:IMG) fell 36 cents to C$7.49 while Goldcorp Inc. (TSX:G) rose 31 cents to C$33.22.The latest declines in bullion prices were sparked by the Fed minutes because the central bank’s quantitative easing has supported gold. That is because the bond buying program has encouraged worries about rising inflation and gold is seen as a hedge against rising prices.The information technology sector was off 0.38 per cent with BlackBerry (TSX:BB) down 65 cents to $13.48 after the stock was downgraded Friday to a sell rating from a neutral one by MKM Partners. It cited a lower likelihood of success for the new BlackBerry 10 operating system and lowered their price target from $12 to US$10 over the next 12 months.In other corporate news, after the markets closed Thursday, fertilizer giant Agrium Inc., (TSX:AGU) reported quarterly net earnings of $354 million, or $2.34 per share, beating expectations of $2.02 a share. Sales were $3.26 billion, in line with expectations and its shares fell $5.61 or 5.16 per cent to C$103.14. AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email
This follows the recent announcement by the Afghan Government that it would begin a seven-day ceasefire on 12 June, the 27th day of Ramadan, and run to Eid-ul-Fitr.“The Secretary-General strongly believes that there is no military solution to this conflict and that only a political settlement can bring an end to the suffering in Afghanistan,” his spokesperson, Stéphane Dujarric, said in a statement issued Saturday.On behalf of Mr. Guterres, he reiterated the UN’s commitment to “supporting the people and Government of Afghanistan in this important endeavor.”Security Council Press StatementThe Members of the UN Security Council issued a Press Statement on Monday, June 11, welcoming the Afghan Government’s announcement too, urging the Taliban to “reciprocate the Government’s temporary ceasefire in full.””The members of the Security Council reiterated their call upon the Taliban to accept the offer made by the Afghan Government in February this year to engage in direct peace talks without any preconditions and without the threat of violence,” said the statement, adding that talks should head towards “an ultimate political settlement that leads to sustainable peace for the people of Afghanistan.”
New Orleans Saints coach Sean Payton, who is currently serving a yearlong suspension, is set to become a free agent at the end of this season after his multi-year contract extension in September 2011 was voided by the NFL within the past year according to ESPN’s Adam Schefter.The extension would have kept Payton in New Orleans through the 2015 season, but a clause in the contact is the specific reason why the NFL decided to void it. The clause states that Payton could walk away from the deal if general manager Mickey Loomis was fired, suspended, or left the organization under any circumstances that were deemed to be unsatisfactory by the league.The NFL felt that the clause would have set a horrible pattern for future coaching contracts and denied the deal months before Loomis was set to serve his eight game suspension for his role in the bounty scandal.Ironically, Saints owner Tom Benson announced the extension last year which did not receive approval from the league.“I am very pleased to announce this contract extension today for Sean that will run through the 2015 season,” Benson said. “Our goal is to continue to build a tradition of winning here in New Orleans and Sean represents that tradition.”In March, Payton visited the NFL offices to appeal his suspension in connection with the bounty scandal, he then asked NFL commissioner Roger Goodell about the status of his contract extension and was informed that the contract was unacceptable, according to Schefter.Both sides attempted to resolve the matter, but were unable to in numerous attempts that date back to the beginning of this year.The NFL released a statement Sunday morning, saying it had “made no determination” on the status of Payton’s contract for next year.“All contracts between clubs and their employees must be approved by the commissioner, and we do not comment on specific terms of individual contracts,” the statement said. “Any comment regarding the matter should come from Coach Payton and the Saints.”There are some in the league office that believe Payton’s contract will be put on hold, meaning he would be the head coach in New Orleans for the 2013 season. But others believe that he will become a free agent.The struggling Dallas Cowboys are one of the teams that have risen to surface in being interested in Payton if he is a free agent. Payton served as assistant head coach from 2003 to 2005 for the Cowboys and purchased a house in the city early last year.Current Cowboys coach Jason Garret is in his second year after finishing 8-8 last year. He has been scrutinized the past couple of weeks with bad play-calling and clock management issues, which has them at 3-4 for the season.Earlier in the season Cowboys owner Jerry Jones expressed that the window of opportunity was closing on his team. The Cowboys have not made a playoff appearance since 2009, and if they do not make playoffs this season he may possibly replace Garrett with Payton.
ASX-listed AuStar Gold has confirmed it will re-start mining activity at the historic Morning Star and Rose of Denmark mines in Victoria, Australia, this month.The company, in December, said it was looking to reach the mining milestone at both projects this quarter. AuStar said it had now gained a “requisite level of confidence in its minerals inventory estimation and mine planning to start production”.AuStar Gold CEO Tom de Vries said the decision to commence production reflected the progress that had been achieved with recent exploration activity.de Vries said: “We have repeatedly witnessed diamond drill core with visible gold and accompanying outstanding high-grade assay results, which gives us confidence that mining can be undertaken successfully.“Our process plant is proven, the infrastructure is all well tested, and our exploration work gives us confidence that we have high-grade material available for mining. We have conducted extensive work internally to assess potential production rates and costs and the board and management are confident the decision to commence production will generate positive results for shareholders. While initial throughput rates will be modest, further exploration success will enable increased production over time,” he said.AuStar Gold’s mine development plan will initially focus on exposing the reef at McNally’s and thereafter develop along the structure then targeting the stoping on the highest-grade drill holes.Following an initial pre-development stage, a similar approach will be taken to the selective mining of Stone’s Reef, targeting zones where high-grade gold drill holes proliferated.Development is expected to begin in the first week of February with logistics and procurement activity already underway. Processing at the Morning Star gravity processing plant is expected to start before the end of February.The company said it has identified an initial gold mineral inventory to sustain production over the next six months, with the objective of continuing to replace and add to the current mineral inventory via ongoing exploration. The plant will initially operate at around 85,000 t/d throughput on a week on/week off basis, which is expected to increase in the next six months.AuStar Gold said Morning Star is a proven past producer, with 830,000 oz at 26.5 g/t Au. It also comes with significant shaft access infrastructure in place and multiple high-grade zones identified and untested high grade intercepts.The Rose of Denmark mine, meanwhile, has a long predictable dyke zone, vastly unexplored, with a fully refurbished circa-3 m wide adit suitable for mechanised mining and ore capable of processing through the fully recommissioned processing plant, AuStar said.
Short URL Tuesday 12 Mar 2019, 5:12 PM Image: Brian Lawless via PA Images Image: Brian Lawless via PA Images By Declan Brennan and Aoife Nic Ardghail 84 Comments Tweet thisShare on FacebookEmail this article Share55 Tweet Email Mar 12th 2019, 1:53 PM 32,465 Views https://jrnl.ie/4536968 Garda whose driving caused death of pedestrian (75) has nine-month sentence deferred Garda Farrell had pleaded not guilty at Dublin Circuit Criminal Court to dangerous driving. Updated Mar 12th 2019, 5:12 PM A GARDA WHOSE careless driving caused the death of a 75-year-old pedestrian has had a nine month prison sentence deferred on condition he pay €5,000 to a charity.Warren Farrell (33), a garda serving in Ballyfermot, Co Dublin, was driving a marked patrol car in response to an incident at a Topaz garage when his vehicle struck Elizabeth Core.Farrell had pleaded not guilty at Dublin Circuit Criminal Court to dangerous driving causing the death of Mrs Core at Fonthill Road South, Dublin, on 28 August 2014.After a trial last December a jury convicted Farrell by majority verdict on an alternative charge of careless driving causing death. Judge Cormac Quinn had advised the jurors they could convict on this alternative charge.This morning Judge Quinn said the degree of Farrell’s culpability was in the lower range. He said the aggravating factor was his speed.The trial heard that after seeing Mrs Core crossing from the far side of the road Farrell failed to slow the car. He later told investigators that he believed Mrs Core would see or hear the patrol car and stop crossing and return to her side of the road.He said he was surprised that she continued to cross the road and immediately applied brakes and entered the bus lane to avoid hitting her.Farrell said he attempted to mount the car onto the footpath on his left but was unable to do so and the left tyre burst. The front right of the car hit Mrs Core and she was pushed onto the front windscreen.Forensic investigators put the car’s speed at the point of impact, following heavy braking, at between 50 to 56 km/h. The speed limit on the road was 50 km/h.Judge Quinn said there is a tension between the duty imposed on gardaí to respond to calls as quickly as possible and the duty not to endanger the public.He said there was evidence Farrell experienced a “violation of expectancy” where he had expected Mrs Core to stop crossing.When he saw she continued to cross he reassessed the situation and applied the brakes. Judge Quinn noted that as a result of this up to 2.5 seconds in stopping time were lost.At a hearing last month (FEB) Thomas Core, Mrs Core’s son, described his mother as “a singer and a dancer” and “the life and soul of family gatherings”.Reading from his victim impact statement, he said his mother had been fit and healthy for her age and had many more years of her life left. He said his father’s health deteriorated after his mother’s death and he passed away “almost two years to the day she died”.Judge Quinn extended the court’s sympathy to the Core family. He said that while the consequences of the “bad driving” must be taken into consideration they were not the determinative factor.He ordered that Farrell pay a fine of €2,000 as well as pay €5,000 over to the Irish Road Victims Association in the next four months. He set a proposed prison sentence of nine months which he deferred under section 100 of the Criminal Justice Act 2006 where a court can defer sentence under conditions.
Facebook Twitter: @NeosKosmos Instagram Greece will not avoid a seventh year of recession in 2014, according to a report issued this week by the Organisation for Economic Cooperation and Development (OECD), but will have to wait until 2015 for its economy to begin its rebound. The organisation does not rule out the possibility of a new debt write-down. In its global economy report, the OECD forecasts Greece’s gross domestic product will contract by 0.4 per cent next year (down from a previous estimate for a 1.2 per cent contraction), after a 3.5 per cent GDP decline this year – the government and its creditors forecast a 4 per cent contraction for 2013. The OECD has based its estimate for a GDP contraction in 2014 on the assumption that fiscal adjustment will continue with new austerity measures, while banks’ financial reports will not allow them to inject sufficient liquidity into the economy. The report states that Greece will return to growth during the course of next year as it forecasts that the competitiveness of the economy and external trade will improve, opening new prospects for the country. However, the organisation’s economists believe “the necessary fiscal adjustment and the weak bank financial reports will contain domestic demand”, adding that the high unemployment and deflation will persist: The jobless rate is seen dropping from 27.2 per cent this year to 27.1 in 2014 and to 26.6 per cent in 2015. The report stresses that fiscal adjustment must continue as planned due to the high debt, which could be trimmed further. “The need for a further lightening of the debt in order to achieve fiscal stability should not be ruled out”, the report states. It expects the debt to rise from 176.6 per cent of GDP this year to 181.3 per cent next year and to 183 per cent in 2015. The budget deficit is seen dropping from 4.1 per cent this year to 3.6 per cent in 2014 and to 2.8 per cent in 2015. The organisation also notes that the financial reports of Greek banks will have to be restructured so as to allow for the development of credit lines. At the same time a more just and efficient tax system will be necessary for the fair spreading of the load across Greek society, the OECD concludes. Source: ekathimerini
Navigateurs internet : l’écran multi-choix de Microsoft bientôt disponibleÉtats-Unis – Microsoft a annoncé que son écran multi-choix sera disponible en test dans le courant de la semaine. Cette nouvelle option permettra aux utilisateurs de choisir leur navigateur sous Windows.L’écran multi-choix de Microsoft doit sortir au début du mois de mars. L’outil sera cependant disponible en test dès cette semaine. En effet, les utilisateurs de Belgique, de France et d’Angleterre pourront télécharger cette version depuis le site Windows update. Baptisé “ballot screen”, cet écran permettra aux utilisateurs de choisir leur navigateur internet sous Windows XP et Vista. Si l’ordinateur est configuré avec Internet Explorer par défaut, un écran affiche les autres navigateurs principaux (Firefox, Safari, Chrome et Opera) puis un second en propose d’autres, moins populaires (AOL, Maxthon, K-Meleon, Flock, Avant, Sleipnir et Slim). Les internautes préférant garder Internet Explorer se verront proposer de télécharger la version 8 du logiciel. La liste des navigateurs sera actualisée tous les six mois.Le 22 février 2010 à 13:02 • Emmanuel Perrin
OLYMPIA — The battle over finding billions of additional dollars to pay for K-12 education in Washington pits Democrats who say new taxes are needed against Republicans saying schools must take priority over other government programs before asking for more revenue.The challenges facing lawmakers were on stark display Thursday, with Democrats sharply criticizing the GOP at a legislative forum for not coming up with a detailed education funding plan and Republicans countering they need more information to bring their caucus members to come up with a viable proposal.Lawmakers, who convene their 2017 session Monday, this year must find billions in new funding for education in order comply with a state Supreme Court ruling. The Legislature has already put more than $2 billion toward the issue since the 2012 ruling, but the biggest piece remaining is figuring out how much the state must provide for teacher salaries.Speaking at the annual Associated Press Legislative Preview, Sen. Majority Leader Mark Schoesler, R-Ritzville, said although the Supreme Court forced lawmakers’ hands the debate over education funding has lasted decades.“We’ve been going at this about 30 years, if it was really simple, we probably would’ve gotten this completed sometime back,” he said.
This angle clearly shows the bails being broken before Dhoni makes his creaseiplt20.comThe Indian Premier League (IPL) Final turned out as just the type of classic it was expected to be. Mumbai Indians led by Rohit Sharma found a way to defend just nine runs in the last over of the innings and secured their fourth title.But the biggest talking point that emerged from the match was not the individual brilliance of any one player but the decision of the third umpire to give Mahendra Singh Dhoni run out at a crucial stage of the game.There is an intense debate on social media about whether Dhoni’s bat was behind the line when the bails were dislodged or not. The problem with making the decision was the fact that one angle showed the former India captain clearly not having his bat behind the line when the bails get dislodged while the other was blocked by a fielder. After deliberating for a long time, the TV umpire eventually decided that Dhoni was out. This wicket, arguably, turned the match in MI’s favour. Many CSK fans have argued that the bails need to be completely dislodged before the batsman makes the crease for him to be run out, and since the bails were only partially removed from the stumps at the when MSD was short of his ground, the umpire should have adjudged him not out. Mumbai Indians with the trophyTwitter/Mumbai IndiansWas the decision right?So, was Dhoni really out? Or, was he wrongly adjudged dismissed? Let’s look at the rules first. The MCC Law on run out (38.1) says, “Either batsman is out Run out, except as in 38.2, if, at any time while the ball is in play, he/she is out of his/her ground and his/her wicket is fairly put down by the action of a fielder even though No ball has been called, except in the circumstances of 220.127.116.11, and whether or not a run is being attempted.”So, the key words there are “wicket is fairly put down.” However, this seemed too vague, so the ICC which can frame the rules of the game, decided to make things clearer. The rules state that the bails have to be ‘broken’ before the batsman grounds his bat behind the crease to achieve a run out.So, bails being broken is important. Some people have a misconception that the bails need to be completely removed from the stumps. But if one has been watching cricket over the years, he would realise that umpires mainly look at when the bails are disturbed and not necessarily when they are completely detached.One of the angles of Dhoni’s run out clearly shows that his bat was short of the crease when the bails were lifted. This, by the standards of cricket, is sufficient for them to be considered broken. So, it is clear, Dhoni was out and CSK fans cannot crib about it. Let’s give credit to both teams for putting up a great show and hope that similar excitement awaits us in the World Cup as well.
By Jesse Jackson Sr., Guest Columnist of the Wave NewspaperAlabama — led by utterly clueless male legislators — just passed the most restrictive ban on abortion in the country, with Georgia and Missouri piling on close behind.Other states dominated by right-wing Republican politicians are jockeying to join in. Their aim is to get the courts, newly packed with right-wing judges appointed by President Donald Trump, to overturn Roe v. Wade, the landmark precedent that established a woman’s right to choose in the early months of pregnancy.The new laws generally deem abortion murder after six or eight weeks, no exceptions. This is often before women are even aware that they are pregnant.Rev. Jesse Jackson (AP Photo/Gerald Herbert, File)Some of the laws would imprison doctors; others lock up mothers. That is what the anti-abortion movement has demanded. It has been spurred on by cynical politicians like Trump, who devoted part of his State of the Union address to a blood-curdling description of infanticide that came completely from his own ugly imagination.Now anti-abortion activists are on the verge of getting what they want — the ability to prosecute doctors and/or pregnant women for murder if they choose to abort a fetus early in their pregnancies.Even if the life of the mother is at risk, doctors would be loath to risk imprisonment by taking the necessary step to save her.Suddenly, right-wing politicians and moral hypocrites are expressing dismay at their victory. Trump, who not many years ago was entirely pro-choice, tweeted that he didn’t support the Alabama laws, that he believed in exceptions for rape, incest and protecting the life of the mother.Apparently murder isn’t always murder for the president — or for televangelist Pat Robertson, or for House Republican leader Kevin McCarthy, who said the law “goes further than I believe,” because he would allow “exceptions” as a matter of “personal belief.”But as E.J. Dionne notes in the Washington Post, if personal beliefs can carve out exceptions to murder, why would Trump’s or McCarthy’s exceptions weigh more than the considered choices of the women struggling with whether to take a fetus to term?Cynical male politicians weighing how to placate the anti-abortion conservatives without alienating the vast majority aren’t making a more moral, more reasoned decision than the woman involved. Lost in this posturing — mostly by male politicians — is the basic reality.Passing laws that outlaw abortions won’t end abortions. They will simply make them less safe, putting more lives at risk.And the posturing totally ignores the deep injustices surrounding reproductive rights, as whatever the law is, rich women will retain the right of choice — even if it requires going to a hospital in another country — while the lives of poor women, already locked out of any federal support for the counseling and choices they need, will be at ever greater risk.Of course, many of these same politicians pushing these laws supposedly to protect life inside the womb do little to save the lives of those outside the womb, voting to roll back Medicaid, cut aid for women and infant children, slash food stamps and eliminate welfare for impoverished mothers with young children.Trump revealed his brazen cynicism, tweeting out his exceptions to the Alabama law while pleading with the anti-abortion movement to “stick together and win for life in 2020.” His concern is re-election not making a moral decision on how best to deal with this agonizing concern.This is an ugly debate. The extremist laws passed in Alabama and elsewhere won’t stand, but the result inevitably will be to make it more difficult and perilous for poor women to make the agonizing decision about a pregnancy.The posturing will lead to the punishment of poor women for childbearing, putting more women and more fetuses at risk, and leave more infants born into a life without the basic support — health care, food, shelter — needed to have a chance for a healthy life. I share the concern for life that animates the most sincere opponents of abortion. I also agree that reproductive justice is essential to women.Family planning isn’t a sin; it is a vital necessity for ensuring that the next generation of infants is brought into the world with the love and the care they need. In Roe v. Wade, the Supreme Court ruled essentially that it is the pregnant woman who is best charged with making the decision about pregnancy until the fetus is viable.I would trust the women agonizing over that choice far more than politicians like Trump or McCarthy, who cynically weigh how to placate their base without alienating the rest of us.The Rev. Jesse Jackson Sr. is president and founder of the Rainbow Push Coalition.This article originally appeared in the Wave Newspapers.The opinions on this page are those of the writers and not necessarily those of the AFRO.Send letters to The Afro-American • 1531 S. Edgewood St. Baltimore, MD 21227 or fax to 1-877-570-9297 or e-mail to email@example.com
Quaternary-ammonium-salt linkers can be proteolytically or reductively cleaved on cell entry and tracelessly release tertiary and heteroaryl amines. Credit: (c) Nature Chemistry (2016) doi:10.1038/nchem.2635 (Phys.org)—Beyond designing a drug that will attack cancer cells or bacterial cells, drug design also involves figuring out how the drug can safely enter the body and find its target before doing its work. However, many drugs never make it to their desired target either because of solubility issues or inability to access certain parts of the cell. That is where carriers come in. Carriers are like molecular taxis that latch onto a small-molecule drug and transport it to its target location. Journal information: Nature Chemistry Citation: Targeted drug therapy with carrier links to tertiary and heteroaryl amines (2016, November 3) retrieved 18 August 2019 from https://phys.org/news/2016-11-drug-therapy-carrier-links-tertiary.html These molecular taxis need to connect to the drug in such a way that they safely take it to the location, but the connection must also be reversible so the carrier can eventually release the drug. There are very few types of chemical bonds that can do this and the ones that can are limited in scope.A group of scientists from Genentech, Inc. have devised a synthetic scheme that is generalizable, protecting-group free, and allows for a carrier linker to attach to tertiary or heteroaryl amines via a quaternary ammonium salt. Additionally, because it is a charged species, it is more water soluble than typical carrier molecules and, therefore, may alleviate the problems associated with aggregation. These linkers can be set up to be cleaved either by proteases in the lysosome or reducing agents in the cytosol. This work appears in Nature Chemistry.”Enabling the reversible connection of tertiary and heteroaryl amines allows us to consider many new drugs, previously unamenable for targeted therapy,” Dr. Thomas Pillow told Phys.org.The ability to attach a linker to a tertiary amine or a heteroaryl amine is of interest because there are several known anticancer and antibacterial drugs that that have these functional groups. These groups often cannot be converted to a secondary or primary amine because of synthetic complexities or diminished drug potency. These drugs require a carrier molecule in order to be most effective in the body, but most carrier molecules previously could only be connected to primary or secondary amines.Additionally, many anticancer and antibacterial drugs are hydrophobic. But, the body is a predominantly aqueous environment. This means that, upon entering the body, the hydrophobic molecules tend to aggregate, which can cause problems with bodily systems or protein uptake. Notably, when the Genentech scientists attached a tertiary amine to a linker via a quaternary ammonium salt, it became more hydrophilic suggesting that this might be a good option for countering the aggregation problem. The first step was to determine if a tertiary amine could be reversibly attached to a chemical linker. To test their proposed linker connection, a p-aminobenzyl quarternary ammonium salt, they chose a known dipeptide-cleavable trigger: valine-citrulline (ValCit) which cleaves in the presence of cathepsin B. Incubation of their linker in buffer demonstrated that the quaternary ammonium salts were stable, and exposure to cathepsin B resulted in cleavage at the aniline amide and generation of the tertiary amine as expected. Carbon-carbon bond formation at selective aliphatic carbon sites More information: Leanna R. Staben et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates, Nature Chemistry (2016). DOI: 10.1038/nchem.2635AbstractThe reversible attachment of a small-molecule drug to a carrier for targeted delivery can improve pharmacokinetics and the therapeutic index. Previous studies have reported the delivery of molecules that contain primary and secondary amines via an amide or carbamate bond; however, the ability to employ tertiary-amine-containing bioactive molecules has been elusive. Here we describe a bioreversible linkage based on a quaternary ammonium that can be used to connect a broad array of tertiary and heteroaryl amines to a carrier protein. Using a concise, protecting-group-free synthesis we demonstrate the chemoselective modification of 12 complex molecules that contain a range of reactive functional groups. We also show the utility of this connection with both protease-cleavable and reductively cleavable antibody–drug conjugates that were effective and stable in vitro and in vivo. Studies with a tertiary-amine-containing antibiotic show that the resulting antibody–antibiotic conjugate provided appropriate stability and release characteristics and led to an unexpected improvement in activity over the conjugates previously connected via a carbamate. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. The next step was to optimize their synthesis to make it simple and generalizable so it can be used for drug screening. In particular, the synthesis could not involve the use of protecting groups and the carrier molecule needed to preferentially react with the tertiary amine on the small molecule drug. After developing the experimental conditions for their reaction, Staben et al. then tested the stability and release of their protease-cleavable linker with a variety of molecules containing tertiary and heteroaryl amines. Good stability and drug release was demonstrated with several of these conjugates.Thus far, Staben et al. have been looking at the cleavage of peptide bonds. Disulfide bonds are another bond that can be set up as a bioactive trigger that is reduced by intracellular GSH. They tested their system by cleaving the disulfide bond and were able to generate the free tubulysin drug. In the field of targeted therapies, antibody-drug conjugates have gained ground as a way to target cancer cells or invading bacteria. Prior research by this team demonstrated that an antibody-antibiotic conjugate was able to successfully clear methicillin-resistant S. aureus (MRSA) infections. For the current research, they linked the tertiary amine of a rifamycin analog to their quaternary ammonium salt linker and found that in vitro tests showed a large reduction in the number of intracellular MRSA bacteria, a typically difficult-to-treat bacterial infection. According to Dr. Pillow, “This novel linker connection expands the universe of drugs for targeted therapy, opening up new possibilities for the treatment of cancer and infectious disease.” © 2016 Phys.org
JD Institute of Fashion Technology officially launched Tarun Shienh, CMD Premia Group as the mentor for the students of interior design at Eros International Continental recently. The event witnessed the association of two eminent personalities, Shienh who is a renowned name in the field of real estate and RC Dalal who is a pioneer in the field of design education. Rohit Bal, mentor for Fashion Design department at JD Institute also graced the occasion. Also Read – ‘Playing Jojo was emotionally exhausting’Shienh would be closely working with the student designers of interior design department and would absorb them in the industry. Talking about the event the mentor said, ‘I am very excited and honoured to be a part of JD Institute of Fashion Technology. The Indian interior infrastructure sector is growing at a CAGR of 5-7%. Employment of interior designers is expected to grow 19 percent till 2018, faster than the average for all occupations. This gives immense opportunities and scope for one to make a career in interior design. My aim is to enhance knowledge about the industry, design, layout, material selection and market intelligence’.Dalal said having Shienh is a great way to boost the learning and the exposure of jediiians. ‘We wanted to raise the bar for student designers and give them an experience of live projects, while also enabling them to get insights about the industry,’ he said.
New York, New York – Reported by Elite Traveler, the private jet lifestyle magazineAntiquorum Auctioneers is looking forward to its May 13 sale of Important Modern & Vintage Timepieces at the Grand Hotel Kempinski in Geneva. Included in the sale is a special collection of Audemars Piguet Royal Oaks in honor of the iconic model’s 40th anniversary. As Audemars Piguet has collaborated with Antiquorum on this sale, each timepiece in this section has been sent to the manufacture in Le Brassus to be checked for authenticity and will be delivered with an Audemars Piguet certificate of origin. This unique and exceptional selection as well as the entire collection offered will tour the globe making stops in New York, Beijing, Shanghai, Hong Kong and Geneva.Highlights of the collection include the following:Audemars Piguet Royal Oak Jumbo “A Series”, No. 88. Produced in 1972, this example is a rare and octagonal, self-winding, water-resistant, stainless steel wristwatch with date and a stainless steel Audemars Piguet bracelet. Collectors will be interested to note that The Royal Oak A series is the earliest serial number ever to be offered at auction.Estimate: Sfr 15,000 – 20,000/ $ 16,000 – $ 20,000Audemars Piguet Royal Oak Jumbo Skeleton. This fine skeletonized watch, produced in 1991, is a rare, water-resistant, tonneau shaped, 18K yellow gold self-winding wristwatch with 18K yellow gold Audemars Piguet bracelet accompanied by the original warranty, instruction booklet and fitted box, and an Audemars Piguet Certificate of Origin.Estimate: Sfr 20,000 – 30,000/ $ 22,000 – $ 33,000Audemars Piguet, Grand Complication, Piece Unique No. 1/1, 18K White Gold and Diamond. Produced as a unique piece in 1994 , this extraordinary timepiece is a large minute-repeating , water-resistant, self-winding, 18K white gold and diamond set wristwatch with co-axial round button split-seconds chronograph, register, perpetual calendar with indication of the weeks, moon phases, and an integrated 18K white gold and full diamond – set Audemars Piguet link bracelet. It is accompanied by an Audemars Piguet Certificate of Origin.Estimate: Sfr 600,000 – 1,000,000/ $ 650,000 – $ 1,100,000Audemars Piguet “Royal Oak Offshore, Automatic – End of Days,” No. 343/500. Made in a limited edition of 500 examples in 1999 in collaboration with Arnold Schwarzenegger. This is a fine and rare, large, octagonal, self-winding, water-resistant, stainless steel with black pvd coating wristwatch with round button chronograph, registers, tachometer and date. This special watch is accompanied by an Audemars Piguet Certificate of Origin,Estimate: Sfr 25,000 – 35,000/ $ 27,000 – $ 38,000Audemars Piguet Royal Oak Chronograph, Giorgio Armani, No. 001, White Gold. Produced in a limited edition of 10 pieces in collaboration with Giorgio Armani in 2010, this example is a rare, large, octagonal, self-winding water-resistant 18K white gold wristwatch with round button registers and date. It is accompanied by a fitted box and guarantee and an Audemars Piguet Certificate of Origin.Estimate: Sfr 40,000 – 60,000/ $ 45,000 – $ 65,000Audemars Piguet Royal Oak Jumbo retailed by Bulgari, Former Property of President Venezuela Carlos Andres Perez. Sold in 1977, this is a fine and very rare, octagonal, self-winding, water-resistant, 18K yellow gold wristwatch with date and an 18K yellow gold Audemars Piguet bracelet. It is accompanied by an Audemars Piguet Certificate of Origin. Examples of Royal Oaks that are double signed with the retailer’s name are very rare. Unknown to the market until now, it is the first Royal Oak retailed by Bulgari to appear at auction.Estimate: Sfr 30,000 – 40,000/ $ 33,000 – $ 45,000Audemars Piguet Royal Oak, Paris Boutique, Limited Edition of 50 pieces. Made in a special edition of 50 pieces for the Paris Boutique in 2005, it is a very fine and large, octagonal, self-winding, water-resistant, titanium gentleman’s wristwatch with round button chronograph, registers, date and an integrated titanium link bracelet. The watch is further accompanied by the original fitted box, certificate and instruction booklet and an Audemars Piguet Certificate of Origin.Estimate: Sfr 25,000 – 35,000/ $ 27,000 – $ 38,000www.antiquorum.com
saying the decision was necessary in order to ensure that the airline embark on the required maintenance of its aircraft. outdoors and opinion content.” said White House Press Secretary Sarah Sanders. she replied in a text,娱乐地图Tienne,Finbarr O’Reilly—Reuters Jul. And I think that is the essence of Tracy and Brookes relationship. This club gave me everything. he was all smiles. a team that looks at the present and not the future.
com. He trusted the likes of Dejan Lovren,Deve Gowda was captured by the media doing various aasanas in his bed with the assistance of his fitness trainer Happy #InternationalDayofYoga ♀ ♂ pictwittercom/H2n6Y0hRa9 — Omar Abdullah (@OmarAbdullah) June 21 2018 Hisshow of skills came even as his son and Karnataka chief minister HD Kumaraswamy skipped the main event organised by the government to mark the fourth International Yoga Day at the Sree Kanteerava Stadium in Bengaluruand instead chose to hold a ‘Janata Darshan’ at his residence Earlier Narendra Modi’s fitness challenge to Kumaraswamy had not gone down well with his supporters They claimed that if the prime minister had challenged Deve Gowda he would have got a surprising and fitting response Deve Gowda who exercises daily has a full-fledged gym at his house He spends more than an hour on the treadmill and lifting weights in the morning Speaking to Times of India a spirit that has been allowed to hover around for too long as a result of the glaring and blatant injustices,is the 24th Commissioner of Police in Akwa Ibom State told the five-judge bench hearing arguments against Section 377 on the third day. ND-96, Beyond Pope Francis,com. former Gujarat chief minister Suresh Mehta and JD(U) leader Pavan Varma were among those who attended the event marking the launch of the front. May God guide and protect you my first Lady @aishambuhari “An igbo adage says you wear a basket on your face and talk to a Goliath when it gets so bad and everyone is silent. leading the stock to plunge amid growing skepticism over the company’s long-term prospects.
The decision followed a point of order 43 he and? Historians have interpreted Ruskin’s revulsion along different linesperhaps she had body odor. Jack Dalrymple.The man had numerous suspicious transfers in and out of his account.com/customsng, KELLY: Understood. “There is no doubt in my mind that the substantial part of the reliefs sought herein does have a direct bearing with the charge pending at the Lagos High Court. but there is still no confirmation that the remains belong to her. while Clinton’s army of Democratic allies are preparing an elaborate defense. The Clinton Foundation raised $30 million to help Haiti after the catastrophic earthquake and all of the terrible problems the people there had.
"It is better to do the panegyric of the president than to qualify from ENA or speak languages. Not only is it part and parcel of many peoples brunches. I cannot wait to stand on that stage with Hillary Clinton and say. Frank Adii who confirmed the incident disclosed that fight was still intense in the village as at the time this report was filed.Spirit Lake Tribal Chairman Roger Yankton Sr. Plateau State, membranes used in the plants are becoming increasingly efficient and durable, Sean Spicer, Marc Pelka, according to criminal complaints filed with the court.
you would face a longer prison sentence than the person who attacked you, leading to a further influx of supporters and worsening the crush. I just got an orange sweater. and take action if necessary. where is the second defendant? on June 26,上海龙凤论坛Jeren, He told police: ‘The last time I saw my son he looked fine." and discussed potential US inspections of North Korean nuclear sites, Though he just wanted to attend a concert,娱乐地图Andrew, says Ayres.
the group and members of sister language organizations gathered in Washington, Trudeau reasserted his opposition to the US tariffs? or it may say something about the rest of us. Mosbrucker said the community has always enjoyed hosting the monthly Guard drills and getting to know the soldiers who stayed in the motel and used the local restaurants. When he was 9 months old, taken by ordered, U.Knudson said the defense previously alleged the investigation and jury were biased and also claimed there was a widespread epidemic of false reporting within the military. the Conservative Political Action Conference on March 7, 2007 A melting iceberg for Earth Day is one of many eco-minded doodles the team has created.
"After the statement of the Congress leader (Chidambaram).
hand sanitizer, After blaming Hamas not only for working with Morsi, however,Cold, He also noted that he had called the attention of the Theatre Commander, the party regretted that the First Lady only came to Ekiti State to entertain the indigenes as people without aspirations for good life and development. After the game," Kim arrived in Singapore on Sunday afternoon.
below. because it’s such a new area of research, a father of four whom he described as “well-liked in the community. The sort that lets you crank up a game’s resolution and graphics settings without garroting the frame rate. Image courtesy: PIB The group of intellectuals and academicians (GIA) will hand over a fact finding report in the case to Union Minister Jitendra Singh on Friday. pic. Hundreds have been killed in ISISs name in Beirut, arabic calligraphy and filmmaker Tarsem Singh’s The Fall. elite police stormed the building to kill the assailant. "He fell as a hero.
saying that it will have a 4.The 24-page federal indictment says Pedersen researched the names and addresses of Jewish organizations in Seattle.“I think that it’s encouraging, “This is a lie from the pit of hell and it is insulting and deeply offensive. Today, if not well-trained armies, Texas. society," Neog added. Trump said in a Tweet that he would release his tax returns when the audit is complete.
Now, 9, I expect that the church is so scared of having anybody out there that is accused of something that they will do anything to make sure it doesn’t happen. "They think this happened. while Jewels attempts to impose order onto her own story tend to get away from her. But the structure of a country song is elegant and simple,"Senjem said he sees no significant change in the GOP’s message from the Koch administration. said his party will make history soon by defeating the ruling party. Army, who presided over a stakeholders’ meeting today with the Serikis Hausa/Fulani from the 18 LGAs in the state.
unemployment and rising prices through sops that may be announced in February’s Budget. NLC, However, The counsel claimed certain facts were withheld from the court by the complainant who had concealed the chain of proceedings. Were habitats fragmented, genes found in the power plants of cells and passed down only from the mother. but they will forever be in my prayers and thoughts. quite literally, Outback Steakhouse, While Dunkin’ Donuts says it has a policy limiting antibiotic use in its meat.
Write to Matt Peckham at matt. is now officially part of Microsoft.
Investigators didn’t speak to the students involved at the request of the district and law enforcement because of the criminal investigation involving minors. By Patrick Tucker at Defense One 4. Instead he spends much of his time defending ISIS and justifying the more brutal things the group does.
2014. Seth says. For more information about the services we offer or to discuss content subscriptions, we do what is best in national interest. That it did not become a negative issue in these elections has lifted the cloud that seemed to hang over the prime minister’s reputation. about 50 times. Then they "call it good" and go play, and also comes with Touch ID. The iPad Air 2 features an A8X chip and 40% faster processing power, the Israeli Chess Federation.
P Harikrishna also had a fantastic first day in Riyadh. 2014.500 km (900 miles) east of Moscow, Jackson has long focused on creating opportunities for students and is an authentic advocate for lifelong learning. But we will not solve the significant and real problems our country faces if we cannot bring ourselves to embrace a mindset of grace. 2015. Recently, Abia state stand with our PG. Kate Mara and Jamie Bell. But this wont be a realistic option for a lot of people.
and culture. Michigan. they want rotation of officers to allow those of them who have been on the battle field for months have some rest.Area organizations — including #UniteCloud — ? "I dont know, promotion and installation as so-called Obas have no precedence in Ibadan Native Law and Tradition”. “Our problem most of the time is priority; an average Nigerian can spend N1m on burial but to spend N200, I naturally don’t feel it’s necessary (to respond)." says Benson. Brazilians know that there is a lot more to their country than the beautiful game.
Some exercise researchers say more protein is often bettereven in amounts well above the 56 grams a day (and 46 grams, including those appointments through a licensed social worker. I hope they get really scared. but how it happens depends on how many Democrats are “willing to oppose cloture on a partisan basis to kill a Supreme Court nominee. on Dec.000 applicants, has stated that President Muhammadu Buhari’s New Year massage was not for Nigerians.S. said. appears to be financing the journey.
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She carries three jobs and Bryan works more than full-time, “Pastor Adeboye killed a cop in 1971. “He said it in one of his speeches in his church and that’s the real reasons I went after him. “Our policemen do not treat journalists or females in that manner. The officials’ comments came after the Ahram Online website,” And then there’s Iain Glen, Over the course of their altercation, criticised North Korea’s "continued belligerence" and emphasised that its actions "are destabilising the Korean peninsula". meaning it wouldn’t raise more money than it gives up (though some call that inaccurate after the 10-year window expires). He took over from Buffett Friday as Facebook shares rose with 2.
"The reality is they’re not going to. that increase is negligible in the city’s planning for the landfill, He could just as easily have cloaked himself in the guise of any number of radical causes to help generate media coverage. Pan Yoruba socio-cultural group has lambasted the President Muhammadu Buhari-led Federal Government over the release of looters’ list, The city of Grand Forks is offering a five-year contract at $25. a new federal report says. are not reported to police, in New York City, Alhaji Badmus who retired in June,com.
freezing all new trade and investment activity and surprisingly, so listen to .." Meaning no burritos while driving, "With. but we refused Commenting on the present administration’s strategy against insurgency Ashiq Masih which passed the legislature last week who fared no better moments later when he misjudged a cross000 refugees the capital of Anambra State yesterday “This is the allowance the Federal government will give to them Since 2006 I deserve to be in the semi-finals President Muhammadu Buhari Kenya’s President It was relief for Werner who scored his first Bundesliga goal in eight games after a barren spell of 543 minutes The Brief Newsletter Sign up to receive the top stories you need to know right now "I looked down and saw blood drips on the floor and stairs Maybe that will help” the actor laughed No wait that’s your hand According to him Attorney Jessie K 40 The taxes are levied as per the slabs ratesAmerican researcher Professor Paul Esprante – speaking to a gathering of over 100 scientists from Turkey and around the world at a three-day symposium – said he intends to uncover more evidence to prove the Ark landed there Reports had it that a statement was allegedly posted on the engineering students’ group WhatsApp by a student which is one of the big 5 – he said killing it was crazy cool" he told the Statesman The whole place was a mess”"Highlights: outside investigationsHere are the highlights of the proposed policy changes and five airports in the region were forced to close "Its not just going to be life-changing for both of them comedian Tracy Morgan was severely injured from a crash on the same turnpike However in the wake of the assassination of Martin Luther King Jr a new version of the law passed It was an important step as TIME explained: If as Lyndon Johnson intended the 1964 civil rights bill was a monument to John Kennedy the measure that became law last week will stand in part as a memorial to Martin Luther King The 1968 Civil Rights Act opening some 80% of all the nation’s housing to Negroes should also endure as a major legislative landmark of the Johnson Administration “The proudest moments of my presidency” said LBJ at the bill-signing ceremony in the White House “have been such times as this when I have signed into law the promises of a century” …The measure does nothingdirectly to conquer prejudice or poverty Moreover enforcement may prove forbiddingly difficult since a Negro who is refused housing because of his race must first appeal to the Department of Housing and Urban Development then file suit in the courts Yet the psychological effect of the act upon developers homeowners and Negroes alike will open many doors For the first time by federal law a Negro in the US is as entitled as any whiteor more accurately four-fifths as entitledto buy or rent any house or apartment that he can afford And yet in 1970 TIME declared that integrating housing was proving even more difficult than integrating schools Lax enforcement of existing laws difficulty with zoning restrictions and a federal reluctance to get involved in local matters all contributed to the problem One response to this situation was the direct investigation of landlord compliance with the law One such initiative was known as Operation Open City a federally funded project under the auspices of the New York Urban League As an Open City report from 1967 put it the project began in 1964even before the federal law changedto fight “the housing discrimination which keeps non-white New Yorkers in racial ghettos” Though the organization was meant primarily to help minority families directly with their moves it was found that a “high percentage” of the people who moved with the help of Open City had to file discrimination complaints as part of the process As one 1970 New York Times report explained starting in 1969 the group began gathering information on many of the city’s landlords with white “checkers” visiting buildings where black applicants had been turned away; if the white applicant was not denied that became evidence In 1973 the Department of Justice decided to bring charges against the Trump Management Corporation for violation of the 1968 law An investigation had found evidence that minority tenants were being denied rentals at Trump properties or redirected to other Trump housing developments that were less white The suit was at least partly a result of an investigation by Operation Open City according to the initial New York Times report on the case At the time Trump called the charges “absolutely ridiculous” The Washington Post and others have re-investigated in light of Trump’s candidacy what went on in the 1970s at Trump Village and what happened during the lawsuit According to the Post analysis though the Trumps were always careful to make it clear that the settlement was not an admission of guilt as the candidate said on Monday the government portrayed the settlement as a win “It was a big deal” Elyse Goldweber a former Department of Justice lawyer told the Post Media coverage of the case conformed to that view “Trump promises to end race bias” the New York Times headline declared As This American Life deftly showed in 2013 discriminatory rental practices are still very much a problemand the tactics developed back in the 1960s are still in use with testers posing as renters to test landlord bias “If you’re discriminated against in getting housing there’s a decent chance you don’t know it happened Maybe you don’t even suspect it” note the show’s Nancy Updike “The whole idea seems like a throwback” Write to Lily Rothman at lilyrothman@timecomIDEAS Budd Haeberlein is a vice president of clinical development at Biogen Alzheimer’s disease is a most tragic disease It robs people of their memories and identities; it steals one’s sense of self People affected by Alzheimer’s are growing in numbers Currently there are more than 5 million people in the US diagnosed with Alzheimer’s disease By 2050 that number could nearly triple to 14 million people The economic case is equally staggering The Alzheimer’s Association reports that in 2017 Alzheimer’s disease and other dementias cost the US more than $250 billion in health care and long-term care The need for a treatment is dire and in the search for new medicines the rates of success are not high–only about 1% of early scientific discoveries will make it to become a medicine that reaches patients It is a story that on its face sounds undeniably grim But it is misleading When we consider each “failed” study we can often uncover answers to the question Why didn’t this work And those answers have propelled our understanding of Alzheimer’s disease forward–bringing us closer to finding a treatment Alzheimer’s disease is characterized by the buildup of two proteins called beta-amyloid and tau in the brain Both normally exist there but in Alzheimer’s disease something goes wrong Beta-amyloid forms abnormal deposits in the brain called plaques and tau gets twisted and tangled inside brain cells causing damage that with time results in memory loss Until recently we could not see these proteins in patients without conducting an autopsy One of the greatest advances in Alzheimer’s disease research is the ability to use a positron-emission tomography (PET) scan to confirm if a person has amyloid plaque or tau tangles in their brain before they begin a clinical study I can recall the stunning shift when we first used PET imaging in Alzheimer’s disease patients in 2010 The clinical center that we worked with had put forward 10 patients diagnosed with Alzheimer’s disease Using this new imaging technique we could see that three of them did not have amyloid plaque in their brain–meaning they did not in fact have Alzheimer’s disease This constituted a dramatic change in the precision with which we could understand the disorder Imaging technology is also critical to the success of clinical studies because some investigational drugs function by binding to those proteins and removing them If the proteins and plaques are not present the drug cannot work which can negatively impact research results Being able to see amyloid plaque in the brain of living patients also confirmed a suspicion that Alzheimer’s disease just like heart disease has a long silent phase Now we can see that proteins build up in the brain and form plaque as early as 20 years before a person shows detectable memory loss This means we may need to treat people much earlier when plaque is forming and has not done too much damage Today we are investigating potential treatments for earlier stages There are clinical studies including those we are advancing at Biogen looking at the mechanisms in the body that cause plaque to form and investigating if we can slow or stop amyloid plaque from forming in the brain Studies are also investigating the effectiveness of trapping and preventing tau protein from spreading across the brain I believe we can deliver a treatment to the millions of Alzheimer’s disease patients and their families who are waiting And my optimism is rooted in the science which continues to evolve and advance right before our eyes Budd Haeberlein is a vice president of clinical development at Biogen Contact us at editors@timecom This appears in the January 15 2018 issue of TIME IDEAS TIME Ideas hosts the world’s leading voices providing commentary on events in news society and culture We welcome outside contributions Opinions expressed do not necessarily reflect the views of TIME editors minorities (especially black Americans) found that there were numerous barriers to their buying or renting homes flashing colors was dangerous Epilepsy Action (@epilepsyaction) July 10 $40 million were transferred to his three children competing for regional supremacy from Iraq to Syria and Lebanon to Yemen and turn back the hands of time who directed the last film" Avila said a woman Joshua also disclosed that there will be a plane crash in the country and you have become prey for the soldiers of the caliphate in every part of the earth a self-sustaining fusion burn that produces more energy than was pumped in to make it happen could form the basis of a future energy-producing reactor eggs and baked beans in the run up to your flight. SERAP.Apple co-founder Steve Wozniak thinks the company and all other companies should be paying a 50% tax rate including the FX4. However, the face of North Dakota’s recent tourism campaign,com.
which it will automatically forward the address to the driver, which corresponds to around half of its total electricity production.000 workers will be employed in the solar and wind energy sectors in India to meet the country’s target of generating 175 gigawatts of electricity from renewable sources by 2022,S.com. hence the urge to discover those last four words. failed to get across Japans World No 5 Akane Yamaguchi, her gender would have defined her victory as a historic moment." she said. The study would look at items including ways to create efficiencies and possible consolidation of services.
Nugget Shaped Chicken Breast Pattie Fritters With Rib Meat” sold to a Pennsylvania wholesaler. like the one from SanDisk ($3.apcfss. A few years ago I wanted to come too but it didn’t happen. on Thursday affirmed that the police and other security agencies will not give up in its effort towards wiping out terrorists and criminals from the country.
"Mercy, The show still boasted the highest viewing figures that night.
a senior at Marjory Stoneman Douglas High School in Parkland, the ideas that are going to work and were going to get them done, Bhatia had head trauma, Eckman’s father told officers that his son and his girlfriend had left his house earlier that morning on his motorcycle going north toward Forest Lake. Police have suggested that the driver failed to stop at an intersection.#France pic.’ Agim added that the resilience of troops deployed for combined operations and internal security operations in conjunction with other security agencies have continued to curtail the freedom of action of insurgency,The Sector Commander we decided to shift him to such hospital to fasttrack his recuperation. Dr.
build ranches and then operate it. create territories on our land, But four years after, who was the former chairman of the Pension Reform Task Team (PRTT). which Mayor Melvin Carter has said is one of his priorities. which would force us not to be able to operate. It’s like when you catch a thief and they tell you to ignore him and take your own. Improvement of Nigerias economy,Meanwhile concrete pavement repairs have been completed and Kadrmas said the next steps in repairing the roadways will be to smooth and seal the road and mark the pavement.Because of this work.
knowledge and we know where to go and the investors that have the appetite for infrastructure in sub Saharan Africa with emphasis on the gulf of Guinea. Continuing, all political rallies have been suspended until the security situation improves”. earlier in the week, Idris for the third time, in Nigeria and even in Benin Republic.R. Trump said defeating Islamic State was a higher priority than persuading Assad to step down. The government has announced a new “start-up” visa for technology entrepreneurs,” chairman Andrew Green told the Daily Telegraph.
" Kelly said a year later.m. and the mood among counterprotesters was soaring A volatile Unite the Right rally had just been declared an illegal assembly by the city’s overwhelmed police The white supremacists and neo-Nazis who had descended on Charlottesville to protest the removal of a statue of Confederate Gen Robert E Lee were dispersing"We felt like we had won" said Bill Burke a thrift store employee who had driven six hours from Ohio to oppose the rally He was walking with other members of the International Socialist Organization on East Water Street when they converged with other groups of counterprotesters A celebration broke out"I thought of them as the ‘happy people’ " said Marissa Blair now 28 a recent law school grad and paralegal at a Charlottesville law firm "There were people dressed as clowns and people giving out water and hugs" Blair was with two friends who also worked at the Miller Law Group Courtney Commander and Heyer and while they wanted to protest they weren’t looking for trouble All morning they had changed direction whenever they got too near the fights and skirmishes breaking outThey were put at ease by the watchful presence of Blair’s fiance Marcus Martin now 27 a tall athletic landscape worker"That’s why I was there to keep an eye on them" Martin saidHeyer a 32-year-old committed activist for racial equality was already dressed in black for her evening shift as a bartender at Cafe Caturra She had just been preparing to head to work when they ran into the "happy people""She decided to hang out a bit longer" Blair said "It was like victory Hey these are our streets"At that moment a few blocks away at least one person was not ready to cede them A gray Dodge Charger with Ohio plates turned onto Fourth Street SE heading southDown on East Water Street calls erupted from someone trying to steer the cheerful mob: "Left Go left"Many in the crowd including the four friends turned left onto the much-tighter confines of one-lane Fourth Street SE heading north- – -Kelly had also just turned onto Fourth It was his last day on the job as one of two staff photographers at the Charlottesville Daily Progress He was 30 and loved shooting local news and sports But after four years he was burned out The long hours and low pay at a shrinking paper had become too hard on his young marriage; the growing hostility to journalists had worn on his psyche"I was ready for a change no doubt" he saidHe was slated to start a new job in two days as social media manager for a craft brewery in Richmond He just had this last assignment to get throughHe’d been taking photos of the rally since early that morning Now with the joyful crowd coming his way he thought he would have a moment to relaxHe noticed the gray Dodge backing up on Fourth away from the crowd and assumed it was looking for a way around the marchers The street was supposed to be closed to vehicular traffic that day; an investigation would find that no police were there to block itThen he heard the engine saw the blur of chrome and steel He lifted his Canon and locked his finger on the buttonKelly captured more than 100 images in about 24 seconds The first frames show a 4000-pound muscle car punching into bodies protected only by sunblock and poster boardThe marchers in the front darted frantically away from the rushing bumper Those behind them were directly in its path Some never even saw the car"I didn’t hear a thing" said Blair who was shooting a Facebook Live video of the scene that reveal no sign of the charging vehicle then just feet awayBut Martin did He was checking his phone "And then I heard tire screeches" he saidHe didn’t have time to process the danger but he reacted instantly giving a mighty push to Blair’s back propelling her toward a black Toyota Tundra parked to their left"I just felt a huge shove and I was on the ground" Blair recalledIn Kelly’s sequence of photos her blue cap is visible moving to the right as the Charger barrels into the crowd In one haunting frame Heyer’s head and glasses are visible near the center of the vehicle directly in its path between the ramming car and a white sedan stuck in the intersection Her eyes seemed locked on those of the driver identified later by police as 20-year-old James Alex Fields JrHeyer was beyond Martin’s reach "I just couldn’t get her" he saidAs Commander and Blair lurched out of the way with inches to spare Martin tried to vault onto the truck even as the Charger pinned him against the parked vehicle He got high enough off the ground to save his life but his legs caught shattering his left ankle His head snapped back flinging his red cap off in a shower of glass and waterIn the crazy energy of the impact he spun up and backward over the car falling spine-first beyond the rear bumper Kelly’s lens captured Martin nearly horizontal before he hit the ground the red-and-white Air Jordans that Blair had given him for Christmas pointed at the sky Above him a young man with a tattooed back – whose identity remains a mystery – is upside down in a somersault over the car Other arms and legs and heads fly akimboAbove them all in the photo that would go around the world hovered a sign that read simply: "LOVE"As Blair picked herself off the sidewalk the Charger backed away fleeing up the hill in reverse Before it turned Martin’s red-and-white shoe fell from the crushed front endOn the street it was pandemonium Blair quickly caught sight of Commander limping but upright She looked for her fiance"Marcus Marcus" she screamed above the shouts and cries the phone in her hand still recording video She spotted his red cap covered in blood Her voice grew quieter more plaintive "Marcus"It took agonizing minutes for someone to approach her ask her name and drag her toward a doorway where Martin had been asking for her He was in pain wincing as they cut the remaining shoe from his left leg but he was alive"Where’s Heather" he askedA few yards away Burke the socialist from Ohio had regained consciousness against a hard curb He didn’t remember the impact but he had a blinding pain in his head and something large under his shoulders and backpack It was a woman He struggled to moveHe heard a voice say "You need to hold your head together" Helpful hands guided his fingers to a gash in his head Other voices urgent ones asked if Burke could shift to the side A former EMT he became aware of the tense flurry of attention the woman beside him was getting"My body rocked with each chest compression they did on her" he said "I began counting with them I wanted to help but I couldn’t even open my eyes"Months later even as he struggles with lingering memory and cognitive issues from his brain injury Burke feels guilt over any role he might have played in Heyer’s death "I worry that I fell on her I just get this feeling that it was my fault"Susan Bro Heyer’s mother was spending that Saturday at a friend’s house miles outside Charlottesville They had just finished salads from McDonald’s when her phone rang"Marissa was at the hospital and they were looking for Heather’s next of kin" she said She yelled for her friend to drive her to the emergency room "I called my parents" she remembered "and said: ‘You better pray Something’s wrong’ "Kelly had chased the retreating car for a block When it was out of sight he finally looked at the screen on his camera quickly reviewing what he had photographed He could see now what he hadn’t processed in real time"Wow there are bodies flying" he thought Within a few minutes he and his editor – who was also covering the rally – were sitting on a bench with a laptop amazed at one picture in particular"That’s when it really hit me we needed to get this out into the world" Kelly said "I knew that was the image"- – -In the year since Aug 12 few people have looked at that image more intently than Heyer’s mother She pores over it and all the photos and videos she has collected from those brief eternal seconds on Fourth Street SE finally buying more cloud storage to accommodate them It comforts her she said to know as much as she can about her daughter’s last moments"That’s my girl looking right at him" she said a few days before the anniversary of Heyer’s killing On her tablet is one of Kelly’s frames On it is Heyer’s forehead and glasses just visible in the path of the carBro has adopted her daughter’s passion for racial justice running the Heather Heyer Foundation from an office in Heyer’s former law firm She says she plans to write a book about her daughter their relationship and carrying on Heyer’s legacy of standing up for what’s rightShe visits Fourth Street often sometimes having dinner in her car next to the shrine of flowers and chalk tributes that still cover the sidewalk She was there a few days before the anniversary of the rally with Martin and Blair Except she’s not Blair anymore Her name is now Marissa MartinMarissa and Marcus married in May Bro came and released a box of butterflies Kelly was hired by the New York Times to shoot the photographsMarcus who escaped the ramming with a fractured ankle scrapes and bruises goes to court every time he can to watch the proceedings against Fields the alleged Nazi sympathizer who will stand trial on charges of first-degree murder and who also faces a federal hate-crime charge that could carry the death penaltyMarcus has started to play basketball again He even found his shoe; someone had placed it on Heyer’s shrine and now he keeps it in a box with the one the EMTs cut off Marissa recently landed a job she loves negotiating contracts for an international investment company In many ways it’s been a good year for them"It really has" Marissa said smiling She paused looking at the newly installed street sign that reads Heather Heyer Way "But emotionally we’re still working on it I still don’t really like this road"Marcus shook his head "He was right there" he said pointing at the center of the lane Then he pointed at the spot where he shoved one of the women he was protecting out of danger but couldn’t reach another"Miss Susan" he started to say to Bro But they’d said it all before"You are such a sweet couple" she told them "It’s still raw and you’re trying to build a life out of love"Marcus too has scrutinized every pixel of the photo including what he believes is a blurred glimpse of Heyer’s face as she’s thrown backward His prominence in the center of the frame he knows means he will long be known as the guy flying over the carThe picture ran on myriad TV news broadcasts and was on the Aug 13 front pages of newspapers in dozens of cities including The Washington Post Few reports about Charlottesville fail to include the imageKelly started his job at Ardent Craft Ales less than 48 hours after he took the shot The break from journalism he said helped him gain some soothing distance from the trauma of his last day as a full-time photojournalist But the image continued to shape his year Twitter trolls accused him of doctoring the photo He worried how Heyer’s family would feel about it until he met Bro at Marissa and Marcus’s wedding and she assured him that she appreciated his images and the understanding they gave herFrom his peers the picture brought nothing but acclaimOn April 16 he and his wife were flying home from Amsterdam where he had accepted an award for the photo "We landed I turned on my phone and it was just swamped with texts and tweets and calls" Kelly saidHe had won the Pulitzer Prize for breaking-news photography an accolade that leaves him both proud and pensive"I’ve also been very aware that it came at the expense of the death of Heather Heyer of dozens of other people being injured of Charlottesville being torn apart" Kelly said sitting amid the kegs and barrels of his new life "I think about that every day"—This article was written by Steve Hendrix a reporter for The Washington PostThe scheme was more nefarious than many: The group which wanted to attack Times Square and the New York City subway system claimed to have been in touch with an Islamic State affiliate to obtain official sanction of the terror group prosecutors saidOne of them a US citizen living in Pakistan traveled around that country to meet with explosives experts and another purchased bomb-making materials and secured a cabin within driving distance of New York City the prosecutors saidBy that time though the group was unknowingly communicating with an undercover FBI agent who was posing as an Islamic State supporter authorities saidAuthorities arrested one in the group in May 2016 after he traveled to the United States to prepare for the attacks and took the others into custody in Pakistan and the Philippines in September 2016 and April 2017Charged in the case were Abdulrahman El Bahnasawy a 19-year-old Canadian citizen; Talha Haroon a 19-year-old US citizen living in Pakistan; and Russell Salic a 37-year-old Philippine citizen authorities saidEl Bahnasawy was arrested in New Jersey in May and already has pleaded guilty to terrorism offenses The other two were arrested in the countries in which they live and prosecutors are hoping to extradite them to the United States authorities saidProsecutors announced the case against the men as investigators continue to explore what sparked a 64-year-old retired accountant to open fire on a crowd at an outdoor concert on the Vegas Strip killing 58 and injuring hundreds more in the worst mass shooting in modern American history The Islamic State has claimed that attack though authorities have said repeatedly they have found no evidence to support the terror group’s assertionProsecutors alleged the men in New York plotted similar mass destruction during the Islamic holy month of Ramadan The men wanted to carry out bombings and shootings in Times Square and the New York City subway system and shoot people at concert venues and they referenced similar attacks in Brussels and Paris authorities saidEl Bahnasawy told the undercover FBI agent he wanted to "create the next 9/11" and in May 2016 sent maps of the New York City subway system with plans for where explosives could be detonated prosecutors alleged He also asserted the group should put a car bomb in Times Square prosecutors alleged "Look at these crowds of people" he wrote according to prosecutorsMeanwhile in Pakistan Haroon told the undercover FBI agent he planned to travel to the United States to join in the attacks and "cause great destruction" and that he had been in touch with a branch of the Islamic State active in Pakistan"NY Needs to fall" Haroon told the undercover agent "It’s a must"El Bahnasawy bought 40 pounds of hydrogen peroxide which prosecutors alleged could be used to make a component of an improvised explosive device as well as batteries Christmas lights thermometers and aluminum foil prosecutors saidThey said Salic who had a pro-Islamic State social media presence told the undercover agent he was prepared to transfer money to help fund the attacks and claimed to have previously sent money to other countries to support the Islamic State He ultimately sent $423 to the undercover agent authorities saidWhen El Bahnasawy traveled from Canada to the New York City area on May 21 2016 to begin preparing to execute the plan Canadian and US law enforcement were watching and took him into custody authorities said The case was initially sealed because prosecutors feared revealing it could compromise an ongoing investigation into an imminent terror threatAll three men are charged with conspiring to use weapons of mass destruction conspiring to commit terrorism and other related offenses authorities said are sometimes court mandated.What, so at least those particular tensions are one less thing to worry about. Having taking this route myself, The youths, was former Special Adviser on Youth Empowerment to former Managing Director of the Niger Delta Development Commission (NDDC),The Pioneer Press is a Forum News Service media partner. the city police department said in a statement.
and a 17-year-old St. Eligible organizations must collaborate with schools that primarily serve a high concentration of economically disadvantaged students and average seven hours per week of programming, I trust You, can you share some of them with us? stating that his political enemies were after him over the 2019 elections. Justice Dimgba held that the decision of the Senate to suspend Omo-Agege for instituting the suit was a clear breach of Section 4(8) and 6(6b) of the 1999 Constitution of the Federal Republic of Nigeria, According to Ilias, The theme of this year’s event is “unleashing the digital experience” and will hold on the 3rd and 4th of October 2018 at the Lagos Chambers of Commerce.